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蛋白质分选以及糙面内质网与高尔基体复合体之间膜泡运输的途径。

Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex.

作者信息

Saraste J, Kuismanen E

机构信息

Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.

出版信息

Semin Cell Biol. 1992 Oct;3(5):343-55. doi: 10.1016/1043-4682(92)90020-v.

Abstract

Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway. Localization of resident marker proteins has shown that this compartment consists of both peripheral and central elements. The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface. We propose a model which describes how mobile, endosome-like elements of the pre-Golgi compartment function in the generation of the compositional and functional boundary between the widely distributed ER and the more centrally located Golgi stacks.

摘要

最近的研究结果越来越多地证明,在粗面内质网和高尔基体复合体之间存在一个中间膜区室,它似乎在蛋白质分选以及胞吐途径早期的膜运输调节中发挥作用。驻留标记蛋白的定位表明,这个区室由外周和中央元件组成。本综述的目的是将高尔基前区室的数据与之前关于内质网-高尔基体界面膜运输的观点结合起来。我们提出了一个模型,该模型描述了高尔基前区室中类似内体的移动元件如何在广泛分布的内质网和位置更居中的高尔基体堆叠之间形成成分和功能边界的过程中发挥作用。

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