Lavoie Christine, Paiement Jacques
Département de pharmacologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC, Canada, J1H 5N4.
Histochem Cell Biol. 2008 Feb;129(2):117-28. doi: 10.1007/s00418-007-0370-y. Epub 2008 Jan 3.
The endoplasmic reticulum (ER) is a key organelle of the secretion pathway involved in the synthesis of both proteins and lipids destined for multiple sites within and without the cell. The ER functions to both co- and post-translationally modify newly synthesized proteins and lipids and sort them for housekeeping within the ER and for transport to their sites of function away from the ER. In addition, the ER is involved in the metabolism and degradation of specific xenobiotics and endogenous biosynthetic products. A variety of proteomics studies have been reported on different subcompartments of the ER providing an ER protein dictionary with new data being made available on many protein complexes of relevance to the biology of the ER including the ribosome, the translocon, coatomer proteins, cytoskeletal proteins, folding proteins, the antigen-processing machinery, signaling proteins and proteins involved in membrane traffic. This review examines proteomics and cytological data in support of the presence of specific molecular machines at specific sites or subcompartments of the ER.
内质网（ER）是分泌途径的关键细胞器，参与合成 destined for multiple sites within and without the cell的蛋白质和脂质。内质网的功能是在翻译过程中和翻译后修饰新合成的蛋白质和脂质，并将它们分类以便在内质网内进行日常维护以及运输到远离内质网的功能位点。此外，内质网还参与特定外源性物质和内源性生物合成产物的代谢和降解。已经有各种蛋白质组学研究报道了内质网的不同亚区室，提供了一个内质网蛋白质词典，许多与内质网生物学相关的蛋白质复合物，包括核糖体、转位子、外套蛋白、细胞骨架蛋白、折叠蛋白、抗原加工机制、信号蛋白和参与膜运输的蛋白，都有新的数据可用。本综述研究了蛋白质组学和细胞学数据，以支持内质网特定位点或亚区室存在特定分子机器。 （注：原文中“destined for multiple sites within and without the cell”表述似乎不太完整准确，可能影响整体译文的精准度）
