Guntinas-Lichius O, Wittekindt C
Clinic of Otolaryngology, Head and Neck Surgery, University of Cologne, Germany.
DNA Cell Biol. 2003 Sep;22(9):593-606. doi: 10.1089/104454903322405473.
Growth factors are a large family of polypeptide molecules that regulate cell division in many tissues by autocrine or paracrine mechanisms. Depending on what receptors are activated, growth factors can initiate mitogenic, antiproliferative, or trophic effects, that is, growth factors act as positive or negative modulators of cell proliferation. Therefore, growth factors do not only play an important role in embryonic development and adult tissue homeostasis, but also in pathological situations like infection, wound healing, and tumorigenesis. Consequently, the application of growth factors, or vice versa the application of substances which are directed against growth factors like antigrowth factor antibodies, may have therapeutic applications. This review provides a brief account of what we know regarding growth factors in otorhinolaryngology, particularly in the field of otology, wound healing, oncology, peripheral nerve regeneration, and rhinology.
生长因子是一大类多肽分子，通过自分泌或旁分泌机制调节许多组织中的细胞分裂。根据激活的受体不同，生长因子可引发促有丝分裂、抗增殖或营养作用，也就是说，生长因子可作为细胞增殖的正性或负性调节因子。因此，生长因子不仅在胚胎发育和成人组织稳态中发挥重要作用，在感染、伤口愈合和肿瘤发生等病理情况下也发挥重要作用。因此，生长因子的应用，或者反之，针对生长因子的物质如抗生长因子抗体的应用，可能具有治疗用途。本综述简要介绍了我们在耳鼻咽喉科，特别是耳科学、伤口愈合、肿瘤学、周围神经再生和鼻科学领域对生长因子的了解。
