Medina Sánchez M, Rodríguez Sánchez C, Vega Alvarez J A, Menéndez Peláez A
Department of Surgery, University of Oviedo, Spain.
Histol Histopathol. 1992 Oct;7(4):607-10.
The neuromuscular junctions (NMJ) from rectus femoris muscle in streptozotocin (STZ)-induced diabetic rats were examined by electron microscopy eight weeks after the STZ injection. When compared to controls and vehicle-injected groups, both the axon terminal and the junctional sarcoplasm showed serious alterations including mitochondrial degeneration, presence of myeloid bodies, breakdown of presynaptic membrane and changes in the form of the synaptic vesicles. The results suggest that NMJ can contribute to the pathogenesis of diabetic proximal myopathy.
在链脲佐菌素（STZ）注射八周后，通过电子显微镜检查STZ诱导的糖尿病大鼠股直肌中的神经肌肉接头（NMJ）。与对照组和注射赋形剂组相比，轴突终末和接头肌浆均出现严重改变，包括线粒体变性、髓样体的存在、突触前膜破裂以及突触小泡形态改变。结果表明，神经肌肉接头可能参与糖尿病近端肌病的发病机制。
