Medina-Sanchez M, Rodriguez-Sanchez C, Vega-Alvarez J A, Menedez-Pelaez A, Perez-Casas A
Departmento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad de Oviedo, Spain.
Am J Anat. 1991 May;191(1):48-56. doi: 10.1002/aja.1001910105.
The response of rat quadriceps muscle fibers to chronic streptozotocin (STZ) diabetes was studied. Transverse sections of rectus femoris muscle from diabetic and weight-matched control rats were assayed for myofibrilar adenosine triphosphatase (ATPase) and nicotinamide adenine dinucleotide-tetrazolium reductase (NADH-TR). A quantitative analysis was carried out by an automatic interactive analysis system focused on the fiber type size and distribution. STZ-induced diabetes caused important effects in this muscle, with changes in the distribution of oxidative enzyme reactions, type I fiber hypertrophy, and type II fiber atrophy, which was greater in type IIB than in type IIA. It is concluded that hypoinsulinism produces morphological alterations in proximal skeletal muscle fibers that are similar to those of neurogenic myopathy. Thus the pathological changes in these mammalian muscle fibers could explain the clinical syndrome seen in diabetic patients called "diabetic symmetrical proximal motor neuropathy," perhaps the least understood of the major neuropathic complications of diabetes.
研究了大鼠股四头肌纤维对慢性链脲佐菌素（STZ）诱导糖尿病的反应。对糖尿病大鼠和体重匹配的对照大鼠的股直肌横切片进行肌原纤维腺苷三磷酸酶（ATPase）和烟酰胺腺嘌呤二核苷酸 - 四氮唑还原酶（NADH - TR）检测。通过自动交互式分析系统对纤维类型大小和分布进行定量分析。STZ诱导的糖尿病对该肌肉产生重要影响，氧化酶反应分布改变、I型纤维肥大和II型纤维萎缩，其中IIB型纤维萎缩比IIA型更明显。结论是胰岛素缺乏在近端骨骼肌纤维中产生形态学改变，类似于神经源性肌病。因此，这些哺乳动物肌肉纤维的病理变化可能解释了糖尿病患者中出现的临床综合征“糖尿病对称性近端运动神经病”，这可能是糖尿病主要神经病变并发症中最不为人所理解的。
