Kessing L V, Agerbo E, Mortensen P B
Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark.
Psychol Med. 2003 Oct;33(7):1177-84. doi: 10.1017/s0033291703007852.
It is unclear whether there is an interaction of ageing on the association between major life events and onset of depression.
This was a population-based nested case-control study with linkage of the Danish Psychiatric Central Research Register and the Integrated Database for Longitudinal Labour Market Research. The study includes data on all admissions at psychiatric wards in Denmark from 1981 to 1998 and data on sociodemographic variables and death/suicide of first-degree relatives.
A total of 13 006 patients who received a diagnosis of depression at the first ever admission at a psychiatric ward and a gender- and age-matched control group of 260 108 subjects were identified. A recent divorce and recent unemployment and suicide of a relative (mother, father, sibling, child, spouse) were associated with increased risk of being admitted for the first time ever at a psychiatric ward with a diagnosis of depression whereas death of a relative by causes other than suicide had no significant effect. In general, no interaction was found with age with any of the variables, totally, or for men or women, separately.
The susceptibility to major life stressors does not seem to change throughout life.
目前尚不清楚衰老是否会对重大生活事件与抑郁症发病之间的关联产生相互作用。
这是一项基于人群的巢式病例对照研究，将丹麦精神病学中央研究登记册与纵向劳动力市场研究综合数据库相链接。该研究包括1981年至1998年丹麦所有精神病病房入院患者的数据以及社会人口统计学变量和一级亲属死亡/自杀的数据。
共识别出13006例在精神病病房首次入院时被诊断为抑郁症的患者，以及一个由260108名受试者组成的性别和年龄匹配的对照组。近期离婚、近期失业以及亲属（母亲、父亲、兄弟姐妹、孩子、配偶）自杀与首次因抑郁症诊断而入住精神病病房的风险增加相关，而亲属非自杀原因导致的死亡则无显著影响。总体而言，未发现年龄与任何变量之间存在相互作用，无论是总体上，还是分别针对男性或女性。
对重大生活压力源的易感性似乎在一生中不会改变。
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