Lu Catherine, Fuchs Elaine
Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065.
Cold Spring Harb Perspect Med. 2014 Feb 1;4(2):a015222. doi: 10.1101/cshperspect.a015222.
The human body is covered with several million sweat glands. These tiny coiled tubular skin appendages produce the sweat that is our primary source of cooling and hydration of the skin. Numerous studies have been published on their morphology and physiology. Until recently, however, little was known about how glandular skin maintains homeostasis and repairs itself after tissue injury. Here, we provide a brief overview of sweat gland biology, including newly identified reservoirs of stem cells in glandular skin and their activation in response to different types of injuries. Finally, we discuss how the genetics and biology of glandular skin has advanced our knowledge of human disorders associated with altered sweat gland activity.
人体覆盖着数百万个汗腺。这些微小的盘绕管状皮肤附属器产生汗液，汗液是我们皮肤冷却和保湿的主要来源。关于它们的形态学和生理学已经发表了大量研究。然而，直到最近，关于腺性皮肤如何维持体内平衡以及在组织损伤后如何自我修复仍知之甚少。在这里，我们简要概述汗腺生物学，包括腺性皮肤中新发现的干细胞库及其对不同类型损伤的反应激活。最后，我们讨论腺性皮肤的遗传学和生物学如何增进了我们对与汗腺活动改变相关的人类疾病的认识。
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