Hubbell Jeffrey A
Institute for Biological and Chemical Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Ecublens, Switzerland.
Curr Opin Biotechnol. 2003 Oct;14(5):551-8. doi: 10.1016/j.copbio.2003.09.004.
Within native tissues cells are held within the extracellular matrix (ECM), which has a role in maintaining homeostasis, guiding development and directing regeneration. Efforts in tissue engineering have aimed to mimick the ECM to help guide morphogenesis and tissue repair. Studies have not only looked at ways to mimick the structure and characteristics of the ECM, but have also considered ways to reproduce its molecular properties including its bioadhesive character, proteolytic susceptibility and ability to bind growth factors.
在天然组织中，细胞被包裹在细胞外基质（ECM）中，细胞外基质在维持体内平衡、引导发育和指导再生方面发挥着作用。组织工程学的努力旨在模仿细胞外基质，以帮助引导形态发生和组织修复。研究不仅着眼于模仿细胞外基质的结构和特性的方法，还考虑了再现其分子特性的方法，包括其生物粘附特性、蛋白水解敏感性和结合生长因子的能力。
