Koyama Junko, Morita Izumi, Kobayashi Norihiro, Osakai Toshiyuki, Hotta Hiroki, Takayasu Junko, Nishino Hoyoku, Tokuda Harukuni
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658, Japan.
Cancer Lett. 2003 Nov 10;201(1):25-30. doi: 10.1016/s0304-3835(03)00467-1.
As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some naphthoquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the naphthoquinones on Epstein-Barr virus early antigen activation. It has been further shown that the correlation can be enhanced by introducing an electronic property, i.e. the atomic charges at the C(4) and O(10) atoms in the quinone skeleton ring as additional parameters.
作为我们使用天然和合成产物作为癌症化学预防剂研究的延续，我们通过循环伏安法在pH 7.2的磷酸盐缓冲液中检测了一些萘醌的标准氧化还原电位。已发现氧化还原电位与萘醌对爱泼斯坦-巴尔病毒早期抗原激活的抑制作用之间存在明确的相关性。进一步表明，通过引入电子性质，即醌骨架环中C(4)和O(10)原子处的原子电荷作为附加参数，可以增强这种相关性。
