Kapadia G J, Balasubramanian V, Tokuda H, Iwashima A, Nishino H
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Howard University, Washington, DC 20059, USA.
Cancer Lett. 1997 May 19;115(2):173-8. doi: 10.1016/s0304-3835(97)04726-5.
Natural colorants such as anthocyanins, betalains, carotenoids, curcuminoids and chlorophylls have been widely used in the food processing industry and in beverages. Most of these colorants constitute part of human dietary components and are considered to be harmless and non-toxic. As a part of the study of natural products to identify non-toxic cancer chemopreventive agents, we have investigated several natural colorant extracts from vegetables and fruits of daily human consumption for their cancer chemopreventive action using the short-term in vitro assay which involves inhibition of Epstein-Barr virus early antigen activation (EBV-EA) induced by phorbol esters. Our study has identified several plant extracts that show profound activity in the EBA assay.
花青素、甜菜色素、类胡萝卜素、姜黄素类和叶绿素等天然色素已广泛应用于食品加工业和饮料中。这些色素大多构成人类饮食成分的一部分，被认为是无害无毒的。作为鉴定无毒癌症化学预防剂的天然产物研究的一部分，我们使用短期体外试验研究了几种日常食用蔬菜和水果中的天然色素提取物的癌症化学预防作用，该试验涉及抑制佛波酯诱导的爱泼斯坦-巴尔病毒早期抗原激活（EBV-EA）。我们的研究已鉴定出几种在EBA试验中表现出显著活性的植物提取物。
