蒽醌对爱泼斯坦-巴尔病毒激活的抑制作用：与氧化还原电位的相关性。

Inhibitory effects on Epstein-Barr virus activation of anthraquinones: correlation with redox potentials.

作者信息

Koyama J, Tagahara K, Osakai T, Tsujino Y, Tsurumi S, Nishino H, Tokuda H

机构信息

Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Japan.

出版信息

Cancer Lett. 1997 May 19;115(2):179-83. doi: 10.1016/s0304-3835(97)04734-4.

DOI:10.1016/s0304-3835(97)04734-4

PMID:9149122

Abstract

The redox potentials have been determined for nine anthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the anthraquinones on the EBV-EA activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e. the atomic charge at O12 as an additional parameter.

摘要

通过循环伏安法测定了9种蒽醌在pH 7.2的磷酸盐缓冲液中的氧化还原电位。已发现蒽醌的氧化还原电位与其对EBV-EA激活的抑制作用之间存在明确的相关性。进一步表明，通过引入一种电子性质，即O12处的原子电荷作为附加参数，可以使这种相关性更好。