Rhee Sang-Hoon
Department of Dental Biomaterials Science, College of Dentistry, Seoul National University, Seoul 110-749, South Korea.
Biomaterials. 2004 Mar-Apr;25(7-8):1167-75. doi: 10.1016/j.biomaterials.2003.08.004.
Effect of poly(epsilon-caprolactone) (PCL) content on the bioactivity and mechanical properties of PCL/silica hybrid was investigated. The PCL/silica hybrids with different PCL contents were prepared through co-condensation reaction with triethoxysilane end capped PCL and tetraethyl orthosilicate. The higher the PCL content in the hybrid, the lower the apatite-forming rate and showed polymer-like ductile-tough fracture behavior. On the contrary, the lower the PCL content in the hybrid, the higher the apatite-forming rate and showed ceramic-like hard-brittle fracture behavior. At the intermediate PCL content, the apatite-forming rate and its mechanical properties showed also intermediate behaviors. The highest tensile strength and Young's modulus could be obtained at intermediate PCL content and they were around 20 and 600 MPa, respectively, while the strain at failure was around 50%. This new kind of hybrid material is likely to have the potential to be used as a bone repairing material because of its apatite-forming ability and the mechanical properties comparable to human cancellous bone.
研究了聚己内酯（PCL）含量对PCL/二氧化硅杂化材料生物活性和力学性能的影响。通过三乙氧基硅烷封端的PCL与原硅酸四乙酯的共缩聚反应制备了具有不同PCL含量的PCL/二氧化硅杂化材料。杂化材料中PCL含量越高，磷灰石形成速率越低，并表现出类似聚合物的延性-韧性断裂行为。相反，杂化材料中PCL含量越低，磷灰石形成速率越高，并表现出类似陶瓷的硬脆性断裂行为。在PCL含量处于中间值时，磷灰石形成速率及其力学性能也表现出中间行为。在PCL含量处于中间值时可获得最高的拉伸强度和杨氏模量，它们分别约为20MPa和600MPa，而断裂应变约为50%。这种新型杂化材料因其磷灰石形成能力以及与人体松质骨相当的力学性能，有可能具有用作骨修复材料的潜力。
