Bogdanov N N, Voronina T A
Biull Eksp Biol Med. 1989 Aug;108(8):199-202.
The influence of diazepam (1; 5; 10 mg/kg, i. p.), chlorpromazine (1 mg/kg) and amphetamine (1; 5 mg/kg) on the Fourier's spectral EEG power of sensomotor cortex and dorsal hippocampus and conflict behavior freely moving albino and cotton (Sigmondon hispidus) rats was studied. Effects of diazepam (5 mg/kg) in cotton rats were similar, but influence on the theta-activity was more expressed. Correlation between slowing of theta-activity and extent of anxiolytic effect in conflict situation was showed. On the basis of the results obtained the authors discuss possible mutual relations between the influence of diazepam on EEG and anxiolytic effect of benzodiazepines.
研究了地西泮（1、5、10毫克/千克，腹腔注射）、氯丙嗪（1毫克/千克）和苯丙胺（1、5毫克/千克）对自由活动的白化大鼠和棉鼠（刚毛棉鼠）感觉运动皮层和背侧海马的傅里叶频谱脑电图功率以及冲突行为的影响。地西泮（5毫克/千克）对棉鼠的影响相似，但对θ活动的影响更明显。显示了θ活动减慢与冲突情境中抗焦虑作用程度之间的相关性。基于所得结果，作者讨论了地西泮对脑电图的影响与苯二氮䓬类药物抗焦虑作用之间可能的相互关系。
