Serrano-Dueñas M
Clínica de Trastornos del Movimiento, Servicio de Neurología, Hospital Carlos Andrade Marin, Quito, Ecuador.
Rev Neurol. 2003;37(7):623-6.
The sialorrhea has been recognised as one of the manifestations of Parkinson's disease, with a frequency of up to 80%. The evolution of patients with sialorrhea is unknown.
We study 26 male and 17 female patients with Parkinson's disease and sialorrhea.
Evaluation at three years showed that sialorrhea had persisting in 18 of them, at six years showed that persisted in 8 patients. We found significant impairment in the sialorrhea group.
If we accept the principle, that sialorrhea are levodopa-resistant disorders as non nigrostriatal symptoms, secondary to a diffuser and more extended cerebral stem degeneration, we could assume that in these patients with sialorrhea cortical-sub cortical circuits are more widely involved leading to motor and cognitive impairment and depression.
流涎已被认为是帕金森病的表现之一，发生率高达80%。流涎患者的病情发展尚不清楚。
我们研究了26例男性和17例女性帕金森病伴流涎患者。
三年时的评估显示，其中18例仍有流涎，六年时显示8例仍有流涎。我们发现流涎组有明显损害。
如果我们接受这样的观点，即流涎作为非黑质纹状体症状是左旋多巴抵抗性疾病，继发于弥漫性和更广泛的脑干变性，那么我们可以假设，在这些流涎患者中，皮质-皮质下回路更广泛地受累，导致运动和认知障碍以及抑郁。
