Sánchez-Rivera A E, Corona-Avendaño S, Alarcón-Angeles G, Rojas-Hernández A, Ramírez-Silva M T, Romero-Romo M A
Departamento de Qui;mica, Universidad Autónoma Metropolitana (Iztapalapa), Av. San Rafael Atlixco #186, Col. Vicentina, C.P. 09340, México, D.F., Mexico.
Spectrochim Acta A Mol Biomol Spectrosc. 2003 Nov;59(13):3193-203. doi: 10.1016/s1386-1425(03)00138-0.
The interest in determining the acidity constants of the catecholamines stems from the fact that they play rather an important biological role. The present work reveals the effect of different parameters such as oxygen, light, analysis time and pH on the dopamine oxidation process, where oxygen has an effect on the dopamine oxidation of 40% and up to 20% is attributed to exposure to light as a function of the pH. The application of adequate control on the said parameters (which ensured stability of the dopamine) facilitated the determination of the corresponding three acidity constants, 9.046+/-0.147, 10.579+/-0.148 and 12.071+/-0.069.
对测定儿茶酚胺酸度常数的兴趣源于它们发挥着相当重要的生物学作用这一事实。目前的工作揭示了不同参数（如氧气、光照、分析时间和pH值）对多巴胺氧化过程的影响，其中氧气对多巴胺氧化的影响为40%，高达20%归因于作为pH值函数的光照暴露。对上述参数进行适当控制（确保了多巴胺的稳定性）有助于测定相应的三个酸度常数，分别为9.046±0.147、10.579±0.148和12.071±0.069。
