Fritz Jonathan, Shamma Shihab, Elhilali Mounya, Klein David
Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA.
Nat Neurosci. 2003 Nov;6(11):1216-23. doi: 10.1038/nn1141. Epub 2003 Oct 28.
We investigated the hypothesis that task performance can rapidly and adaptively reshape cortical receptive field properties in accord with specific task demands and salient sensory cues. We recorded neuronal responses in the primary auditory cortex of behaving ferrets that were trained to detect a target tone of any frequency. Cortical plasticity was quantified by measuring focal changes in each cell's spectrotemporal response field (STRF) in a series of passive and active behavioral conditions. STRF measurements were made simultaneously with task performance, providing multiple snapshots of the dynamic STRF during ongoing behavior. Attending to a specific target frequency during the detection task consistently induced localized facilitative changes in STRF shape, which were swift in onset. Such modulatory changes may enhance overall cortical responsiveness to the target tone and increase the likelihood of 'capturing' the attended target during the detection task. Some receptive field changes persisted for hours after the task was over and hence may contribute to long-term sensory memory.
我们研究了这样一个假设，即任务表现能够根据特定的任务需求和显著的感官线索迅速且适应性地重塑皮层感受野特性。我们记录了经过训练以检测任意频率目标音调的行为雪貂初级听觉皮层中的神经元反应。通过在一系列被动和主动行为条件下测量每个细胞的频谱时间反应场（STRF）的局部变化来量化皮层可塑性。STRF测量与任务表现同时进行，在持续行为期间提供了动态STRF的多个快照。在检测任务中关注特定目标频率会持续诱导STRF形状的局部促进性变化，这些变化起效迅速。这种调节性变化可能会增强皮层对目标音调的整体反应性，并增加在检测任务中“捕捉”被关注目标的可能性。一些感受野变化在任务结束后持续数小时，因此可能有助于长期感觉记忆。
