Reinel D, Clarke C
Dermatologische Abteilung, Bundeswehrzentral-krankenhaus, Hamburg, Germany.
Clin Exp Dermatol. 1992 Sep;17 Suppl 1:44-9. doi: 10.1111/j.1365-2230.1992.tb00278.x.
Amorolfine is a new topical antifungal of the phenylpropyl morpholine class which is highly active both in vitro and in vivo against yeasts, dermatophytes and moulds responsible for superficial fungal infections. Human pharmacological studies have established that amorolfine has a persistent antifungal effect in the nail bed and in the skin without being systemically absorbed. This has been confirmed by clinical work showing that amorolfine is effective in treating dermatomycoses and onychomycoses when administered as cream or nail lacquer. It is ineffective when given orally for systemic mycoses or bacterial infections in animals. In earlier studies a 5% concentration of amorolfine nail lacquer was found to produce a better cure rate in onychomycosis than a lower concentration of 2%. From data available on the penetration of amorolfine and on the persistence of mycologically relevant tissue concentrations, it appeared likely that once- or twice-weekly application of nail lacquer should suffice to produce a satisfactory therapeutic effect in onychomycosis. The aim of this investigation was to assess the efficacy and tolerability of 5% amorolfine nail lacquer given once versus twice weekly to patients with onychomycosis of finger nails and toe nails.
阿莫罗芬是一种新型的苯丙基吗啉类外用抗真菌药，在体外和体内对引起浅表真菌感染的酵母菌、皮肤癣菌和霉菌均具有高度活性。人体药理学研究表明，阿莫罗芬在甲床和皮肤中具有持久的抗真菌作用，且不会被全身吸收。临床研究证实，当以乳膏或指甲油形式给药时，阿莫罗芬对治疗皮肤癣菌病和甲癣有效。口服给药对动物的全身性真菌病或细菌感染无效。在早期研究中，发现5%浓度的阿莫罗芬指甲油治疗甲癣的治愈率高于2%的较低浓度。根据阿莫罗芬的渗透数据以及真菌学相关组织浓度的持久性数据，每周一次或两次涂抹指甲油似乎足以对甲癣产生令人满意的治疗效果。本研究的目的是评估每周一次与每周两次给予5%阿莫罗芬指甲油对手指甲和脚趾甲癣患者的疗效和耐受性。
