Aschauer Manuela, Deutschmann Hannes A, Stollberger Rudolf, Hausegger Klaus A, Obernosterer Andrea, Schöllnast Helmut, Ebner Franz
Department of Magnetic Resonance Imaging, University Hospital Graz, Austria.
Magn Reson Med. 2003 Nov;50(5):993-1002. doi: 10.1002/mrm.10607.
The purpose of this study was to determine the value of a blood-pool contrast media (NC100150, Nycomed Imaging (now Amersham Health) Oslo, Norway) for evaluation of venous thrombosis of the deep veins of the pelvis and lower extremities. Twelve patients were prospectively evaluated with conventional X-ray venography (XRV) and MR venography (MRV) after injection of NC100150 (2 ml/kg body weight). The source images and 3D maximum intensity projection (MIP) were viewed on an independent workstation. Diagnosis was made in consensus from two radiologists. Diagnostic image quality was achieved in 87 veins with XRV and MRV. As determined by XRV, thrombus was present in 30 out of 87 veins (34.5%). There was agreement concerning absence or presence of thrombi in 83 out of 87 veins (95.4%; kappa = 0.9 +/- 0.05). Compared to XRV, overall sensitivity and specificity of blood-pool MRV were 93.3% and 96.5%, respectively. Two venous thromboses of the popliteal and posterior tibial vein were diagnosed in MRV, but not in XRV. Conversely, two venous thromboses below the knee had been missed by MRV. NC100150 allows prolonged and improved visualization of the peripheral vasculature and may overcome some limitations of gadolinium contrast media. A more complete examination of the proximal venous tree may be possible than with conventional XRV. Arterial and venous enhancement and motion artifacts can limit image interpretation.
本研究的目的是确定一种血池造影剂（NC100150，挪威奥斯陆奈科明影像公司（现阿美仙健康公司））在评估骨盆和下肢深静脉血栓形成方面的价值。12例患者在注射NC100150（2 ml/kg体重）后，前瞻性地接受了传统X线静脉造影（XRV）和磁共振静脉造影（MRV）检查。源图像和三维最大强度投影（MIP）图像在独立工作站上进行观察。由两名放射科医生共同做出诊断。XRV和MRV在87条静脉中获得了诊断性图像质量。根据XRV检查，87条静脉中有30条（34.5%）存在血栓。87条静脉中有83条（95.4%；kappa = 0.9 +/- 0.05）关于血栓的有无达成了一致意见。与XRV相比，血池MRV的总体敏感性和特异性分别为93.3%和96.5%。MRV诊断出了腘静脉和胫后静脉的两处静脉血栓形成，但XRV未诊断出。相反，MRV漏诊了两处膝下静脉血栓形成。NC100150可延长并改善外周血管系统的显影，且可能克服钆造影剂的一些局限性。与传统XRV相比，可能对近端静脉树进行更全面的检查。动脉和静脉强化以及运动伪影会限制图像解读。
