Horton L, Fox C, Corrin B, Sönksen P H
Br J Cancer. 1977 Dec;36(6):692-9. doi: 10.1038/bjc.1977.251.
Forty-six separate renal tumours developed in 36/80 Wistar male rats given a single i.v. dose of streptozotocin (25 mg/kg body wt) to induce diabetes mellitus. Fourteen of the tumours were epithelial in type, 8 were wholly mesenchymal and 24 were largely mesenchymal but also contained epithelial elements. The purely epithelial tumours correspond to the renal adenomas and adenocarcinomas seen in man. The mesenchymal tumours were composed either of undifferentiated spindle cells or of a mixutre of poorly differentiated mesenchyme and epithelial glands. Microscopically, the mixed tumours resembled the nephroblastomas seen in man; both elements appeared to be malignant, but in the absence of metastases this remains unproven. The management of the diabetic state did not influence the incidence of tumours, but insulin appeared to enhance tumour growth.
给80只雄性Wistar大鼠静脉注射单次剂量链脲佐菌素（25mg/kg体重）以诱发糖尿病，其中36只大鼠发生了46个独立的肾肿瘤。这些肿瘤中，14个为上皮型，8个完全为间充质型，24个主要为间充质型但也含有上皮成分。单纯的上皮肿瘤相当于人类所见的肾腺瘤和腺癌。间充质肿瘤由未分化的梭形细胞组成，或由低分化间充质和上皮腺体的混合物组成。显微镜下，混合性肿瘤类似于人类所见的肾母细胞瘤；两种成分似乎均为恶性，但在无转移的情况下，这一点仍未得到证实。糖尿病状态的控制并未影响肿瘤的发生率，但胰岛素似乎会促进肿瘤生长。
