用于光学纯α-氨基醛和α-氨基酸的通用合成子：(+)-和(-)-4,5-二烷氧基-2-恶唑烷酮。

Versatile synthons for optically pure alpha-amino aldehydes and alpha-amino acids: (+)- and (-)-4,5-dialkoxy-2-oxazolidinones.

作者信息

Morita T, Nagasawa Y, Yahiro S, Matsunaga H, Kunieda T

机构信息

Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

出版信息

Org Lett. 2001 Mar 22;3(6):897-9. doi: 10.1021/ol015535r.

DOI:10.1021/ol015535r

PMID:11263910

Abstract

Both enantiomers of trans-5-benzyloxy-4-methoxy- (BMOx) and trans-4,5-dimethoxy-2-oxazolidinones (DMOx), which are readily accessible from simple 2-oxazolone heterocycles, represent good candidates for a new class of chiral synthons for use in the preparation of optically pure alpha-amino aldehydes and alpha-amino acids, respectively.

摘要

反式-5-苄氧基-4-甲氧基-（BMOx）和反式-4,5-二甲氧基-2-恶唑烷酮（DMOx）的两种对映体分别是制备光学纯α-氨基醛和α-氨基酸的新型手性合成子的良好候选物，它们很容易从简单的2-恶唑酮杂环化合物中获得。