家麝鼩（Suncus murinus）肠道双糖酶：蔗糖酶缺乏症的发生情况。

Intestinal disaccharidases in the house musk shrew, Suncus murinus: occurrence of sucrase deficiency.

Yokota K, Oda S, Takesue S, Takesue Y

Research Institute of Environmental Medicine, Nagoya University, Japan.

Comp Biochem Physiol B. 1992 Nov;103(3):629-34. doi: 10.1016/0305-0491(92)90381-z.

Abstract

Disaccharidase activities of the small-intestinal brush border membrane were studied in six laboratory lines of the house musk shrew, Suncus murinus. 2. Sucrase activity was detected in all shrews of one line, but not in any shrew of three lines. In the other two lines it was found in some shrews, but not in the others. 3. Maltase, isomaltase, trehalase and lactase activities were found in all shrews of all the lines examined. 4. Sucrase was normally associated with isomaltase to form an enzyme complex. 5. Detergent-solubilized isomaltase, whether associated with sucrase or not, was inhibited by antibodies against rabbit sucrase-isomaltase to almost the same extent as the rabbit one, suggesting that isomaltase is not affected by a mutation(s) in sucrase.

摘要

对家麝鼩（Suncus murinus）的六个实验室品系的小肠刷状缘膜双糖酶活性进行了研究。2. 在一个品系的所有麝鼩中检测到了蔗糖酶活性，但在三个品系的任何麝鼩中均未检测到。在另外两个品系中，在一些麝鼩中发现了蔗糖酶活性，但在其他麝鼩中未发现。3. 在所有检测品系的所有麝鼩中均发现了麦芽糖酶、异麦芽糖酶、海藻糖酶和乳糖酶活性。4. 蔗糖酶通常与异麦芽糖酶结合形成酶复合物。5. 经去污剂增溶的异麦芽糖酶，无论是否与蔗糖酶结合，被抗兔蔗糖酶 - 异麦芽糖酶抗体抑制的程度几乎与兔的相同，这表明异麦芽糖酶不受蔗糖酶突变的影响。