Kirby S C, Anderson W M, Chesson A L, George R B
Department of Computer Engineering, Veterans Affairs Medical Center, Shreveport, LA.
Comput Methods Programs Biomed. 1992 Jul;38(2-3):107-15. doi: 10.1016/0169-2607(92)90081-h.
The measurement of oxygenation during sleep has become a standard procedure in the assessment of hypoxemia in patients with various disorders. However, an accepted method for quantitating this hypoxemia is not available. This study describes the development of computerized data acquisition and analysis programs to quantitate nocturnal hypoxemia in patients with sleep and breathing disorders. The acquisition program samples the voltage output from pulse oximeters used to measure oxyhemoglobin saturation (SpO2) and stores this on an IBM PC or compatible computer. The analysis program integrates the SpO2 over time below the patient's pretest baseline as well as the integral below 90, 80, 70, 60 and 50% saturation. We refer to each integral as Saturation Impairment Time or SIT. In order to compare these integrals between patients or between the same patient but different studies, the integral is divided by the total sleep study time. We refer to each of these integrals, corrected for sleep study time, as the SIT index. Evaluation of the SIT index in 10 consecutive patients referred for various sleep disorders revealed acquisition program detection and deletion of 48 of 57 (86%) oximeter probe artifacts (mean duration of 3 seconds for undetected artifacts). There were no significant artifacts in the analysis program calculation of the SIT index in these same patients. In conclusion, computer programs were developed to measure and quantitate oxygen saturation measured by oximeters. Preliminary results reveal an accuracy of measurement which should prove acceptable in further clinical evaluations.
睡眠期间的氧合测量已成为评估各种疾病患者低氧血症的标准程序。然而，目前尚无公认的定量这种低氧血症的方法。本研究描述了用于定量睡眠和呼吸障碍患者夜间低氧血症的计算机化数据采集和分析程序的开发。采集程序对用于测量氧合血红蛋白饱和度（SpO2）的脉搏血氧仪的电压输出进行采样，并将其存储在IBM个人计算机或兼容计算机上。分析程序整合了患者测试前基线以下随时间变化的SpO2，以及饱和度低于90%、80%、70%、60%和50%时的积分。我们将每个积分称为饱和损害时间（SIT）。为了比较不同患者之间或同一患者不同研究之间的这些积分，将积分除以总的睡眠研究时间。我们将这些经睡眠研究时间校正后的积分中的每一个称为SIT指数。对10例因各种睡眠障碍转诊的连续患者的SIT指数进行评估，结果显示采集程序检测并删除了57个脉搏血氧仪探头伪迹中的48个（86%）（未检测到的伪迹平均持续时间为3秒）。在这些相同患者的SIT指数分析程序计算中没有明显的伪迹。总之，开发了计算机程序来测量和定量脉搏血氧仪测得的氧饱和度。初步结果显示测量精度在进一步的临床评估中应该是可以接受的。
