Schram L L, Rubert M, Loewenstein D A
Department of Rehabilitation, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.
Arch Clin Neuropsychol. 1995 May;10(3):255-63.
Intrusive or perseverative errors as evidenced on tests of memory have been found to occur with greater frequency in patients with Alzheimer's Disease (AD) relative to other disorders and are thought to reflect the cholinergic deficits associated with AD. A particular type of intrusive error, semantic intrusions, has been found to discriminate AD from multi-infarct dementia and normal elderly controls. However, it has been suggested that such errors actually reflect random responding as the result of the disinhibition often observed in AD patients. The present study compared the frequency and types of intrusive errors from a sample of mildly, moderately, and more severely impaired AD patients who had undergone the Fuld Object Memory Evaluation with the "guesses" of elderly controls. Results of this study indicate that the semantic intrusions of AD patients differ both in type and frequency from the guesses of the control subjects.
与其他疾病相比，在阿尔茨海默病（AD）患者的记忆测试中，侵入性或持续性错误出现的频率更高，并且被认为反映了与AD相关的胆碱能缺陷。一种特殊类型的侵入性错误，即语义侵入，已被发现可将AD与多发梗死性痴呆和正常老年对照组区分开来。然而，有人提出，此类错误实际上反映的是AD患者中经常观察到的去抑制导致的随机反应。本研究比较了轻度、中度和重度受损的AD患者样本在接受福尔兹物体记忆评估时的侵入性错误的频率和类型，以及老年对照组的“猜测”情况。这项研究的结果表明，AD患者的语义侵入在类型和频率上均与对照组受试者的猜测不同。
