Loewenstein D A, D'Elia L, Guterman A, Eisdorfer C, Wilkie F, LaRue A, Mintzer J, Duara R
Wien Center, Mount Sinai Medical Center, Miami Beach, FL 33140.
Brain Cogn. 1991 May;16(1):104-17. doi: 10.1016/0278-2626(91)90088-p.
Recent evidence suggests that specific types of intrusive errors may occur more often in the protocols of Alzheimer's disease (AD) patients than in those of patients diagnosed with other types of dementia. Using the FULD Object Memory Evaluation, we documented the occurrence of five qualitatively different types of intrusive errors for mildly and moderately impaired patients with AD and multiple cerebral infarctions (MCI). Depressed and normal elderly controls were also studied. Despite an equivalent degree of impairment on a broad array of neuropsychological measures, mildly impaired AD patients evidenced greater deficits on a measure tapping retrieval from semantic memory and demonstrated a higher occurrence of specific types of intrusive errors relative to their mildly impaired MCI counterparts. Further, both of these measures were highly correlated, suggesting that these indices may be particularly sensitive to semantic dysfunction associated with early AD.
最近的证据表明，与诊断为其他类型痴呆症的患者相比，特定类型的侵入性错误在阿尔茨海默病（AD）患者的记录中可能更频繁出现。使用福尔兹物体记忆评估法，我们记录了轻度和中度受损的AD和多发性脑梗死（MCI）患者出现的五种性质不同的侵入性错误。还研究了抑郁和正常的老年对照者。尽管在一系列广泛的神经心理学测量中损伤程度相当，但轻度受损的AD患者在一项衡量语义记忆提取的测量中表现出更大的缺陷，并且相对于轻度受损的MCI患者，特定类型的侵入性错误出现频率更高。此外，这两种测量高度相关，表明这些指标可能对与早期AD相关的语义功能障碍特别敏感。
