Pituitary function before, during, and after chronic gonadotropin-releasing hormone agonist therapy.
作者信息
Cedars M I, Steingold K A, Lu J H, Judd H J, Meldrum D R
机构信息
Department of Obstetrics and Gynecology, University of California-Los Angeles.
出版信息
Fertil Steril. 1992 Dec;58(6):1104-7. doi: 10.1016/s0015-0282(16)55551-4.
OBJECTIVE
To examine possible adverse effects on pituitary function of long-term administration of gonadotropin-releasing hormone agonist (GnRH-a).
DESIGN
Prospective analysis of blood sampling before, during, and after GnRH-a therapy.
SETTING
Tertiary institutional outpatient care.
PATIENTS
Twelve normally ovulatory women with a diagnosis of endometriosis.
INTERVENTIONS
Six-month suppression with GnRH-a.
MAIN OUTCOME MEASURES
Serum levels of follicle-stimulating hormone, luteinizing hormone, free thyroxin index, cortisol (F), growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH).
RESULTS
Basal and stimulated values of gonadotropins, PRL, F, TSH, and GH were normal and unchanged by 6 months of GnRH-a after resumption of menses.
CONCLUSIONS
Utilizing dynamic pituitary function tests, we were unable to demonstrate an adverse effect of long-term GnRH-a therapy on pituitary function.
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