Vasconcellos Luiz Felipe Rocha, Peixoto Maria Claudia, de Oliveira Tatiana Nunes, Penque Glória, Leite Ana Claudia Celestino
University Hospital Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil.
Arq Neuropsiquiatr. 2003 Sep;61(3B):851-4. doi: 10.1590/s0004-282x2003000500027. Epub 2003 Oct 28.
The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.
甲状腺功能减退症患者中肌病的发生率在30%至80%之间。相关的主要症状为肌无力、肌肉痉挛和肌痛。假性肥大形式称为霍夫曼综合征。电生理研究显示为肌病、神经病或混合模式。实验室检查通常显示肌肉酶水平升高以及血清甲状腺激素水平降低，促甲状腺激素（TSH）升高。治疗方法为激素替代，大多数情况下预后良好。我们报告一名成年男性，他出现了肌肉痉挛、肌痛、肌无力、假性肥大，并伴有面部水肿和声音改变。肌肉酶升高，T4检测不到，TSH水平升高。在该病例中，肌病是甲状腺功能减退症的初始表现。
