Gromer Stephan, Urig Sabine, Becker Katja
Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany.
Med Res Rev. 2004 Jan;24(1):40-89. doi: 10.1002/med.10051.
The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized.
由硫氧还蛋白还原酶及其特征性底物硫氧还蛋白组成的硫氧还蛋白系统是细胞内氧化还原环境的重要组成部分。它与许多不同的代谢途径相互作用，如DNA合成、硒代谢和抗氧化网络，以及显著的物种差异，使得该系统成为许多医学领域化疗方法的一个有吸引力的靶点，范围从传染病到癌症治疗。在这篇综述中，我们将呈现并评估目前可得的临床前和临床结果。强调了药物开发的当前趋势。
