Koháryová Michaela, Kollárová Marta
Faculty of Natural Sciences, Comenius University, Department of Biochemistry, Mlynská dolina, 842 15, Bratislava, Slovak Republic.
Gen Physiol Biophys. 2015 Jul;34(3):221-33. doi: 10.4149/gpb_2015006. Epub 2015 Apr 30.
Nowadays there are numerous pathogens that have created a resistance to commonly used antibiotics and drugs. Therefore research is focused on finding new therapeutic targets and on determination of their 3D structures that could help in designing new effective substances and inhibitors. Thioredoxin system not only plays a crucial role as thiol/disulfide redox controller, it is also essential for certain organisms as the only system ensuring the redox homeostasis. It is the redox-regulating function, which makes thioredoxin and thioredoxin reductase attractive for scientific research, especially in many studies of diseases caused by redox instability. Thanks to these facts, the proteins of thioredoxin system are suitable candidates for new therapeutic purposes. In this review we summarized the basic features of the thioredoxin system, we justified why the proteins of thioredoxin system are appropriate therapeutical targets and we provided overview of the possibilities of their inhibition by several types of inhibitors.
如今，有许多病原体对常用抗生素和药物产生了耐药性。因此，研究重点在于寻找新的治疗靶点并确定其三维结构，这有助于设计新的有效物质和抑制剂。硫氧还蛋白系统不仅作为硫醇/二硫键氧化还原控制器发挥着关键作用，对某些生物体而言，它还是确保氧化还原稳态的唯一系统，因而至关重要。正是这种氧化还原调节功能，使得硫氧还蛋白和硫氧还蛋白还原酶成为科学研究的热点，尤其是在许多由氧化还原不稳定引起的疾病研究中。基于这些事实，硫氧还蛋白系统的蛋白质是新治疗用途的合适候选者。在本综述中，我们总结了硫氧还蛋白系统的基本特征，阐述了为何硫氧还蛋白系统的蛋白质是合适的治疗靶点，并概述了几种类型抑制剂对其抑制作用的可能性。
