Singh D K, Narayan K G, Gupta M K
Department of Veterinary Public Health & Epidemiology, Ranchi Veterinary College, Birsa Agricultural University, India.
Indian J Exp Biol. 1992 Apr;30(4):324-6.
Three strains of Bacillus cereus isolated from sausages (Salami and Trekker, RANBAC, Ranchi) produced enterotoxin which caused vascular permeability in skin and haemorrhage in the ligated ileal loops of rabbits. Histopathological studies revealed haemorrhage and congestion in submucosa, mononuclear cell infiltration in lamina propria and submucosa and villous atrophy. Histochemical studies ruled out the effect on mitochondrial enzymes of intestinal epithelial cells. Purified enterotoxin given intradermally to rabbits caused severe necrotic reaction at the site of injection and death within 4 hr. Histopathological changes observed in liver included congestion of portal veins and sinusoids, vacuolar degeneration of hepatocytes, and hyperplasia of bile ducts. These suggested that B. cereus enterotoxin affected the capillaries of blood vessels locally and also systemically resulting into release of proteinaceous exudates and red blood cells.
从香肠中分离出的三株蜡样芽孢杆菌（萨拉米香肠和徒步旅行者香肠中的菌株、RANBAC、兰契）产生的肠毒素可导致兔皮肤血管通透性增加以及结扎回肠袢出血。组织病理学研究显示黏膜下层出血和充血、固有层和黏膜下层单核细胞浸润以及绒毛萎缩。组织化学研究排除了对肠上皮细胞线粒体酶的影响。给兔皮内注射纯化的肠毒素会在注射部位引起严重坏死反应，并在4小时内死亡。肝脏中观察到的组织病理学变化包括门静脉和肝血窦充血、肝细胞空泡变性以及胆管增生。这些表明蜡样芽孢杆菌肠毒素局部和全身影响血管的毛细血管，导致蛋白质渗出物和红细胞释放。
