Rao A R, Kale R K
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Indian J Exp Biol. 1992 May;30(5):367-70.
Estrogenic action of diosgenin on the mammary epithelium of ovariectomized (OVX) mouse has been reported. Diosgenin when administered (sc) at the dose levels of 20 and 40 mg/kg body weight for a period of 15 days stimulated the growth of mammary epithelium. This was indicated by the increase in DNA content, increase in number of ducts and appearance of terminal endbuds. There was a significant increase in the mammary development scores in the presence of diosgenin. Concomitant treatment of estrogen and diosgenin showed augmentation of estrogenic effect of diosgenin especially at the higher dose level (40 mg/kg body wt). Diosgenin showed a lack of progesterogenic action as was apparent from the absence of alveolar development even in the presence of exogenous estrogen.
已报道薯蓣皂苷元对去卵巢（OVX）小鼠乳腺上皮具有雌激素样作用。当以20和40mg/kg体重的剂量皮下给药15天时，薯蓣皂苷元刺激了乳腺上皮的生长。这表现为DNA含量增加、导管数量增多以及终末芽的出现。在薯蓣皂苷元存在的情况下，乳腺发育评分显著增加。雌激素与薯蓣皂苷元联合治疗显示薯蓣皂苷元的雌激素样作用增强，尤其是在较高剂量水平（40mg/kg体重）时。从即使存在外源性雌激素也没有腺泡发育这一点可以明显看出，薯蓣皂苷元缺乏孕激素样作用。
