[Action of epidermal chalone on the vaginal epithelial cell proliferation in ovariectomized mice stimulated by 17 beta-estradiol].

It has been shown that the DNA synthesis inhibitory effect of chalone on the vaginal epithelium of ovariectomized mice administered epidermal chalone three times (8, 4 and 1 h before 17-beta-estradiol injection) is dependent on chalone injection made 1 h before hormone injection. The decrease in the number of DNA synthesizing cells induced by 3-fold injection of chalone during 2 days is linked with the reduction in the level of exogenous estrogen in ovariectomized mice rather than with the duration of epidermal chalone action.