Watanabe Yoshihiko, Cornélissen Germaine, Watanabe Misako, Watanabe Fumihiko, Otsuka Kuniaki, Ohkawa Shi-ichiro, Kikuchi Takenori, Halberg Franz
Tokyo Women's Medical University, Tokyo, Japan.
Clin Exp Hypertens. 2003 Oct;25(7):405-12. doi: 10.1081/ceh-120024984.
Even when the daily blood pressure mean is acceptable, too large a circadian amplitude of blood pressure largely increases cardiovascular disease risk. Autogenic training (N = 11), a non-pharmacologic intervention capable of lowering an excessive blood pressure variability, may be well-suited for MESOR-normotensive patients diagnosed with circadian-hyper-amplitude-tension (CHAT). Not all anti-hypertensive drugs affect blood pressure variability. Accordingly, long-acting carteolol (N = 11) and/or atenolol (N = 8) may be preferred to captopril retard (N = 13), nilvadipine (N = 8), or amlodipine (N = 7) for midline-estimating statistic of rhythm (MESOR)-hypertensive patients with CHAT. Prospective outcome studies are needed to assess whether the relative merits of these treatments are in keeping with their effects on blood pressure and blood pressure variability.
即使每日平均血压处于可接受范围，但血压昼夜波动幅度太大也会大幅增加心血管疾病风险。自生训练（N = 11）是一种能够降低过度血压变异性的非药物干预措施，可能非常适合被诊断为昼夜高振幅血压（CHAT）的MESOR血压正常患者。并非所有抗高血压药物都会影响血压变异性。因此，对于患有CHAT的MESOR高血压患者，长效卡替洛尔（N = 11）和/或阿替洛尔（N = 8）可能比缓释卡托普利（N = 13）、尼伐地平（N = 8）或氨氯地平（N = 7）更受青睐。需要进行前瞻性结局研究，以评估这些治疗方法的相对优势是否与其对血压和血压变异性的影响相符。
