Ghosh S, Bhattacharya S
Department of Zoology, Visva-Bharati University, Santiniketan, India.
Indian J Exp Biol. 1992 Aug;30(8):736-7.
Effect of some pollutants like heavy metals, non-metals and pesticides on the circulating level of C-reactive protein (CRP) which is an acute phase plasma protein was studied in a freshwater murrel C. punctatus. Fish was exposed to nonlethal doses of these xenobiotics which were apparently safe. But the level of CRP detected by sensitive single radial immunodiffusion (SRID) technique showed that within 12 hr of exposure the nonlethal doses of xenobiotics could initiate the acute phase response in terms of elevated CRP titre. Heavy metals caused the acute phase within 24 hr, nonmetals and Metacid-50 within 48 hr exposure. The carbamate compound, carbaryl demonstrated a biphasic response to CRP level which may be correlated with the reversible type of anticholinesterase property of this compound while Metacid-50 is an irreversible type of anticholinesterase agent. The assessment of the CRP level in the serum of fish may be utilized as a primary bioindicator of a contaminated environment toxic enough to mount an acute phase response.
在淡水鳢鱼斑点鳢中研究了一些污染物（如重金属、非金属和农药）对作为急性期血浆蛋白的C反应蛋白（CRP）循环水平的影响。将鱼暴露于这些明显安全的非致死剂量的外源化学物中。但是通过敏感的单向放射免疫扩散（SRID）技术检测到的CRP水平表明，在暴露12小时内，非致死剂量的外源化学物可根据CRP滴度升高引发急性期反应。重金属在暴露24小时内引发急性期反应，非金属和灭虫威-50在暴露48小时内引发急性期反应。氨基甲酸盐化合物西维因对CRP水平表现出双相反应，这可能与其该化合物的可逆型抗胆碱酯酶特性有关，而灭虫威-50是不可逆型抗胆碱酯酶剂。评估鱼血清中的CRP水平可作为受污染环境毒性足以引发急性期反应的主要生物指标。
