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Does circadian variation in risk factors for sudden infant death syndrome (SIDS) suggest there are two (or more) SIDS subtypes?

作者信息

Mitchell E A, Williams S M

机构信息

Department of Paediatrics, University of Auckland, New Zealand.

出版信息

Acta Paediatr. 2003 Sep;92(9):991-3.

PMID:14599054
Abstract

UNLABELLED

Sudden infant death syndrome (SIDS) is known to occur more frequently at night. In two studies it has now been shown that a prone sleep position is more strongly associated with SIDS occurring during the day, whereas night-time deaths are more strongly associated with maternal smoking and illness.

CONCLUSION

This variation, although unexplained, does suggest at least two SIDS subtypes: one related to sleep position and possibly a thermal mechanism, and one related to an uncontrolled inflammatory response to infection predominantly occurring at night. In addition, there are probably other mechanisms that do not show a circadian variation.

摘要

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Exploring the risk factors for sudden infant deaths and their role in inflammatory responses to infection.探讨婴儿猝死的风险因素及其在感染炎症反应中的作用。
Front Immunol. 2015 Mar 5;6:44. doi: 10.3389/fimmu.2015.00044. eCollection 2015.