Eckhardt Matthias, Fu Gregory C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2003 Nov 12;125(45):13642-3. doi: 10.1021/ja038177r.
A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, beta-hydrogen-containing alkyl bromides and iodides under mild conditions. By furnishing the first example of a nonphosphine-based palladium catalyst for cross-coupling unactivated alkyl electrophiles, this study provides an impetus for future efforts at catalyst development that extend beyond phosphine ligands.
一种基于钯/氮杂环卡宾的催化剂能够在温和条件下实现一系列功能化的含β-氢烷基溴化物和碘化物的Sonogashira偶联反应。通过提供首个用于未活化烷基亲电试剂交叉偶联的非膦基钯催化剂实例，本研究为未来超越膦配体的催化剂开发工作提供了动力。
