Perkins Kenneth A, Ciccocioppo Melinda, Jacobs Lynette, Doyle Todd, Caggiula Anthony
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Exp Clin Psychopharmacol. 2003 Nov;11(4):269-75. doi: 10.1037/1064-1297.11.4.269.
Nonpharmacological cues associated with drug intake may influence subjective and reinforcing effects of those drugs. Social drinkers (N = 80) participated in 2 sessions in which they rated and then consumed ad lib their preferred beer (with participants blind to brand). Visual and olfactory stimuli were obscured during 1 session (blocked) and not obscured during the other (unblocked). Dependent measures included ratings of "liking", "want another", and "desire to drink"; subjective mood; and ad lib beer consumption (reinforcement). Most ratings and ad lib consumption were lower during the blocked versus the unblocked condition. There were no interactions of blockade condition with sex and no effect of blockade on mood. These findings show that nonpharmacological stimuli associated with alcohol consumption influence alcohol's subjective and reinforcing effects.
与药物摄入相关的非药物线索可能会影响这些药物的主观和强化效应。社交饮酒者(N = 80)参加了两个环节,他们先对自己喜欢的啤酒进行评分,然后随意饮用(参与者对品牌不知情)。在一个环节中视觉和嗅觉刺激被遮挡(阻断),在另一个环节中不被遮挡(未阻断)。相关测量包括“喜欢程度”“再来一杯”和“饮酒欲望”的评分;主观情绪;以及随意饮用啤酒量(强化效应)。与未阻断状态相比,在阻断状态下大多数评分和随意饮用量更低。阻断状态与性别之间没有交互作用,且阻断对情绪没有影响。这些发现表明,与酒精消费相关的非药物刺激会影响酒精的主观和强化效应。