Bruno Alessandra Nejar, Da Silva Rosane Souza, Bonan Carla Denise, Battastini Ana Maria Oliveira, Barreto-chaves Maria Luiza M, Sarkis João José Freitas
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Avenida Ramiro Barcellos 2600-ANEXO, 90035-003, Porto Alegre, RS, Brazil.
Int J Dev Neurosci. 2003 Nov;21(7):401-8. doi: 10.1016/s0736-5748(03)00088-1.
Here we investigate the possible effects of the hyperthyroidism on the hydrolysis of the ATP to adenosine in the synaptosomes of hippocampus, cerebral cortex and blood serum of rats in different developmental phases. Manifestations of hyperthyroidism include anxiety, nervousness, tachycardia, physical hyperactivity and weight loss amongst others. The thyroid hormones modulate a number of physiological functions in central nervous system, including development, function, expression of adenosine A(1) receptors and transport of neuromodulator adenosine. Thus, hyperthyroidism was induced in male Wistar rats (5-, 60-, 150- and 330-day old) by daily injections of L-thyroxine (T4) for 14 days. Nucleotide hydrolysis was decreased by about 14-52% in both hippocampus and cerebral cortex in 5 to 60-day-old rats. These changes were also observed in rat blood serum. In addition, in 11-month-old rats, inhibition of ADP and AMP hydrolysis persisted in the hippocampus, whereas, in cerebral cortex, an increase in AMP hydrolysis was detected. Thus, hyperthyroidism affects the extracellular nucleotides balance and adenosine production, interfering in neurotransmitter release, development and others physiological processes in different systems.
在此，我们研究甲状腺功能亢进对不同发育阶段大鼠海马体、大脑皮层突触体以及血清中ATP水解为腺苷的可能影响。甲状腺功能亢进的表现包括焦虑、紧张、心动过速、身体多动以及体重减轻等。甲状腺激素调节中枢神经系统中的多种生理功能，包括发育、功能、腺苷A(1)受体的表达以及神经调质腺苷的转运。因此，通过每日注射L-甲状腺素（T4）持续14天，在雄性Wistar大鼠（5日龄、60日龄、150日龄和330日龄）中诱导甲状腺功能亢进。5至60日龄大鼠的海马体和大脑皮层中核苷酸水解均降低了约14%至52%。在大鼠血清中也观察到了这些变化。此外，在11月龄大鼠中，海马体中ADP和AMP水解受到抑制，而在大脑皮层中，检测到AMP水解增加。因此，甲状腺功能亢进会影响细胞外核苷酸平衡和腺苷生成，干扰不同系统中的神经递质释放、发育及其他生理过程。
