Pradel C, Siauve N, Bruneteau G, Clement O, de Bazelaire C, Frouin F, Wedge S R, Tessier J L, Robert P H, Frija G, Cuenod C A
Laboratoire de Recherche en Imagerie, LRI-U494, Faculte Necker, Paris, France.
Magn Reson Imaging. 2003 Oct;21(8):845-51. doi: 10.1016/s0730-725x(03)00186-3.
We describe the use of perfusion-permeability magnetic resonance imaging (ppMRI) to study hemodynamic parameters in human prostate tumor xenografts, following treatment with the vascular endothelial growth factor-A (VEGF) receptor tyrosine kinase inhibitor, ZD4190. Using a macromolecular contrast agent (P792), a fast MR imaging protocol and a compartmental data analysis, we were able to demonstrate a significant simultaneous reduction in tumor vascular permeability, tumor vascular volume and tumor blood flow (43%, 30% and 42%, respectively) following ZD4190 treatment (100 mg/kg orally, 24 h and 2 h prior to imaging). This study indicates that MR imaging can be used to measure multiple hemodynamic parameters in tumors, and that tumor vascular permeability, volume and flow, can change in response to acute treatment with a VEGF signaling inhibitor.
我们描述了灌注-渗透磁共振成像（ppMRI）在研究人前列腺肿瘤异种移植模型血流动力学参数中的应用，该模型在接受血管内皮生长因子-A（VEGF）受体酪氨酸激酶抑制剂ZD4190治疗后。使用大分子造影剂（P792）、快速磁共振成像方案和房室数据分析，我们能够证明在ZD4190治疗（口服100mg/kg，在成像前24小时和2小时）后，肿瘤血管通透性、肿瘤血管体积和肿瘤血流同时显著降低（分别为43%、30%和42%）。这项研究表明，磁共振成像可用于测量肿瘤中的多种血流动力学参数，并且肿瘤血管通透性、体积和血流可因VEGF信号抑制剂的急性治疗而发生变化。
