Rexrode Kathryn M, Pradhan Aruna, Manson Joann E, Buring Julie E, Ridker Paul M
Center of Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.
Ann Epidemiol. 2003 Nov;13(10):674-82. doi: 10.1016/s1047-2797(03)00053-x.
To examine the relationship between different measures of adiposity as predictors of C-reactive protein (CRP) and interleukin-6 (IL-6) levels.
A cross-sectional study of 733 women free from preexisting cardiovascular disease or cancer at baseline.
Total adiposity, as measured by body mass index (BMI). Abdominal adiposity, as measured by waist circumference (WC) and waist/hip ratio (WHR). High sensitivity CRP levels and IL-6 levels.
BMI, WHR, and WC were all significantly correlated with CRP and IL-6, throughout the anthropometric spectrum. After adjustment for risk factors, the odds ratios (ORs) were 12.2 (95% CI, 6.44-23.0) for elevated CRP (>/=75th percentile) and 4.13 (95% CI, 2.37-7.18) for elevated IL-6 (>/=75th percentile) in comparisons of extreme BMI quartiles. Among women in the highest WC quartile, the OR for elevated CRP and IL-6 were 8.57 (95% CI, 4.59-16.0) and 4.40 (95%CI, 2.46-7.89), while ORs for the highest WHR quartile were 2.88 (95% CI, 1.60-5.19) and 1.76 (95% CI, 1.03-3.01), respectively. Compared with lean nonusers, women in the highest BMI quartile who did not use hormone therapy (HT) had an OR for elevated CRP of 7.79 (95% CI, 2.08-29.2) vs. 31.6 (95% CI, 7.97-125.6) for current hormone users.
Indices of both total and abdominal adiposity were strongly associated with significant increased levels of CRP and IL-6. This association was evident across the entire spectrum of BMI.
研究不同肥胖指标作为C反应蛋白（CRP）和白细胞介素-6（IL-6）水平预测指标之间的关系。
对733名基线时无心血管疾病或癌症病史的女性进行横断面研究。
通过体重指数（BMI）测量总体肥胖程度。通过腰围（WC）和腰臀比（WHR）测量腹部肥胖程度。高敏CRP水平和IL-6水平。
在整个身体测量范围内，BMI、WHR和WC均与CRP和IL-6显著相关。在调整危险因素后，在极端BMI四分位数比较中，CRP升高（≥第75百分位数）的比值比（OR）为12.2（95%可信区间，6.44 - 23.0），IL-6升高（≥第75百分位数）的OR为4.13（95%可信区间，2.37 - 7.18）。在WC最高四分位数的女性中，CRP升高和IL-6升高的OR分别为8.57（95%可信区间，4.59 - 16.0）和4.40（95%可信区间，2.46 - 7.89），而在WHR最高四分位数中，OR分别为2.88（95%可信区间，1.60 - 5.19）和1.76（95%可信区间，1.03 - 3.01）。与瘦的非使用者相比，BMI最高四分位数中未使用激素疗法（HT）的女性CRP升高的OR为7.79（95%可信区间，2.08 - 29.2），而当前激素使用者为31.6（95%可信区间，7.97 - 125.6）。
总体和腹部肥胖指标均与CRP和IL-6水平显著升高密切相关。这种关联在整个BMI范围内都很明显。
