Schwartz Benjamin M, Khuntia Deepak, Kennedy Alexander W, Markman Maurie
Division of Gynecologic Oncology, Magee Womens Hospital-University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA.
Gynecol Oncol. 2003 Nov;91(2):421-2. doi: 10.1016/s0090-8258(03)00404-9.
Radiation recall dermatitis secondary to gemcitabine use has been reported in isolated cases of patients treated for breast and lung cancers. There have been no reports of radiation recall dermatitis from gemcitabine after whole pelvic radiation therapy employed as a treatment of a gynecologic cancer.
A 67-year-old woman was treated with whole pelvic radiation for palliation of lower extremity swelling and pain due to recurrent ovarian adenocarcinoma. Three months later, the patient was treated with gemcitabine for three courses. Therapy was discontinued secondary to severe cellulitis and edema of the skin of the anterior abdominal wall in the field of her prior radiation therapy.
Radiation recall dermatitis secondary to gemcitabine should be considered in any patient with pelvic or lower abdominal skin abnormalities after pelvic radiation and subsequent gemcitabine therapy.
在接受乳腺癌和肺癌治疗的患者个别病例中，已报告了使用吉西他滨继发的放射性回忆性皮炎。在采用全盆腔放疗治疗妇科癌症后，尚无关于吉西他滨引起放射性回忆性皮炎的报告。
一名67岁女性因复发性卵巢腺癌导致下肢肿胀和疼痛而接受全盆腔放疗以缓解症状。三个月后，该患者接受了三个疗程的吉西他滨治疗。由于先前放疗区域前腹壁皮肤出现严重蜂窝织炎和水肿，治疗中断。
对于任何在盆腔放疗及随后接受吉西他滨治疗后出现盆腔或下腹部皮肤异常的患者，均应考虑吉西他滨继发的放射性回忆性皮炎。
