Fukasawa Miyuki, Obara Sakaé
Shin-Etsu Chemical Co. Ltd., Specialty Chemicals Research Center, Kibiki-mura, Nakakubiki-gun, Niigata, Japan.
Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1304-6. doi: 10.1248/cpb.51.1304.
The molecular weight of hypromellose phthalate (HPMCP), a polymer used for enteric coating, was determined using size exclusion chromatography with a multi-angle laser light scattering detector. The values of weight-average molecular weight (Mw) of commercially available grades (HP-55, HP-55S, and HP-50) were 45600, 60200, and 37900, respectively. Their inter-day precisions expressed in terms of the coefficient of variation were less than 3%. A correlation curve between Mw and solution viscosity was prepared so that Mw could be easily estimated from the solution viscosity measured by the compendial method.
邻苯二甲酸羟丙甲纤维素（HPMCP）是一种用于肠溶包衣的聚合物，其分子量通过尺寸排阻色谱法结合多角度激光散射检测器进行测定。市售等级（HP - 55、HP - 55S和HP - 50）的重均分子量（Mw）值分别为45600、60200和37900。以变异系数表示的日内精密度小于3%。绘制了Mw与溶液粘度之间的相关曲线，以便可以根据药典方法测得的溶液粘度轻松估算Mw。
