Fukasawa Miyuki, Obara Sakaé
Specialty Chemicals Research Center, Shin-Etsu Chemical Co. Ltd., 28-1 Nishifukushima, Kubiki-mura, Nakakubiki-gun, Niigata 942-8601, Japan.
Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1391-3. doi: 10.1248/cpb.52.1391.
The molecular weight of hypromellose acetate succinate (HPMCAS), a polymer used for enteric coating, was determined by means of size exclusion chromatography with a multi-angle laser light scattering detector. The weight-average molecular weight (Mw) of several lots and grades ranged approximately from 17000 to 20000, and the number-average molecular weight (Mn) was around 13000. The inter-day precision of measurement, in terms of the coefficient of variation, was less than 5%.
醋酸羟丙甲纤维素琥珀酸酯（HPMCAS）是一种用于肠溶包衣的聚合物，其分子量通过配备多角度激光散射检测器的尺寸排阻色谱法测定。几个批次和等级的重均分子量（Mw）约为17000至20000，数均分子量（Mn）约为13000。以变异系数表示的日内测量精密度小于5%。
