Takasawa Masashi, Oku Naohiko, Osaki Yasuhiro, Kinoshita Hiroshi, Imaizumi Masao, Yoshikawa Takuya, Kimura Yasuyuki, Kajimoto Katsufumi, Sasagaki Michihiro, Kitagawa Kazuo, Hori Masatsugu, Hatazawa Jun
Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.
J Cereb Blood Flow Metab. 2003 Nov;23(11):1378-82. doi: 10.1097/01.WCB.0000091258.83091.C2.
Most human manual grip movements can be divided into power gripping and precision gripping, but central neural control during these tasks remains unclear. We investigated activation of the whole brain to analyze how simple hand movements are performed. The cerebral blood flow of seven healthy right-handed volunteers was measured by H2 15O positron emission tomography during right grip tasks without gripping a target object. Auditory-cued, repetitive power grips (i.e., fist making) and repetitive precision grips (i.e., opposition of the tip of the index finger and the tip of the thumb) were performed at 1.26 Hz. The areas activated during both tasks were the left primary sensorimotor cortex, caudal portion of the dorsal premotor, caudal portion of the supplementary motor area, cingulate motor area, and the right spinocerebellum and intermediate region of the cerebrocerebellum in comparison with the rest state. The analysis of power grip-precision grip tasks showed the activated peaks in the upper portion of the left sensorimotor area and right cerebellar vermis, but these areas were activated in both the tasks [(power grip-rest) and (precision grip-rest)] with uncorrected P < 0.001 as the statistical criterion. With P < 0.05 corrected as the statistical criterion, the results showed no significant activated peaks in regional cerebral blood flow. Our findings indicate no difference in brain activation between the acts of power grip and precision grip without a target object.
大多数人类手部抓握动作可分为强力抓握和精确抓握，但这些任务期间的中枢神经控制仍不清楚。我们研究了全脑激活情况，以分析简单手部动作是如何执行的。在右手抓握任务（不抓握目标物体）期间，通过H2 15O正电子发射断层扫描测量了7名健康右利手志愿者的脑血流量。以1.26赫兹的频率执行听觉提示的重复性强力抓握（即握拳）和重复性精确抓握（即食指尖与拇指尖相对）。与静息状态相比，两项任务期间激活的区域为左侧初级感觉运动皮层、背侧运动前区尾部、辅助运动区尾部、扣带运动区以及右侧脊髓小脑和大脑小脑中间区域。对强力抓握-精确抓握任务的分析显示，在左侧感觉运动区上部和右侧小脑蚓部有激活峰值，但这些区域在两项任务[（强力抓握-静息）和（精确抓握-静息）]中均被激活，未校正P<0.001作为统计标准。以校正后P<0.05作为统计标准，结果显示局部脑血流量无显著激活峰值。我们的研究结果表明，在没有目标物体的情况下，强力抓握和精确抓握动作之间的大脑激活没有差异。
