UStün Yakup, Erdogan Ozgür, Esen Emin, Karsli Ebru Deniz
Cukurova University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adana, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Nov;96(5):535-9. doi: 10.1016/S1079210403004645.
The aim of this study was to compare the effects of intravenous administration of 1.5 mg/kg and 3 mg/kg of methylprednisolone sodium succinate (MP) on pain, swelling, and trismus after third molar surgery.
Twenty-six healthy patients with symmetrically impacted mandibular third molars were included in this double-blind, cross-over study. Either 1.5 mg/kg or 3 mg/kg of MP was administered by intravenous route one hour prior to the first operation. At the second operation the other dose was applied. Trismus was determined by measuring maximum interincisal opening and facial swelling was evaluated using a tape measuring method. Pain was determined using visual analogue scale and recording the number of pain pills taken.
There was no statistically significant difference in trismus, facial swelling, and pain between the two groups.
No clinical benefit of the higher dose of MP was demonstrated.
本研究旨在比较静脉注射1.5毫克/千克和3毫克/千克琥珀酸甲泼尼龙（MP）对第三磨牙手术后疼痛、肿胀和牙关紧闭的影响。
本双盲交叉研究纳入了26例双侧下颌阻生第三磨牙的健康患者。在第一次手术前1小时，通过静脉途径给予1.5毫克/千克或3毫克/千克的MP。在第二次手术时应用另一剂量。通过测量最大切牙间开口度来确定牙关紧闭情况，并使用卷尺测量法评估面部肿胀。使用视觉模拟量表确定疼痛程度并记录服用止痛片的数量。
两组之间在牙关紧闭、面部肿胀和疼痛方面无统计学显著差异。
未证明较高剂量的MP有临床益处。
