Naganawa Shinji, Nihashi Takashi, Fukatsu Hiroshi, Ishigaki Takeo, Aoki Ikuo
Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai-cho, Shouwa-ku, 466-8550, Nagoya, Japan.
Eur Radiol. 2004 Jan;14(1):112-4. doi: 10.1007/s00330-003-2147-6. Epub 2003 Nov 5.
The functional magnetic resonance imaging (fMRI) is often performed at the end of a routine MRI examination during which, dependent on the clinical indication, contrast agent has been administered; however, the effects of Gd-DTPA injection on the results of blood oxygenation level dependent (BOLD)-fMRI remain unknown. The present study was conducted to investigate the effects of the intravenous administration of Gd-DTPA on the results of pre-surgical localization of the primary motor cortex by BOLD-fMRI at 3 T. Eight normal subjects were included in this study. After the anatomical scans, pre- and post-contrast fMRI scanning was performed. The number of significantly activated voxels and the mean percentage signal change were compared. The mean number of significantly activated voxels was 115.0+/-27.0 in pre-contrast runs and 90.8+/-27.1 in post-contrast runs (mean value of all 8 volunteers+/-standard deviation; p<0.05). The mean mean percentage signal change was 4.07+/-0.39 in pre-contrast runs and 3.86+/-1.91 in post-contrast runs ( p=0.16). Pre-surgical localization of the motor area by BOLD-fMRI should be performed before the administration of Gd contrast material.
功能磁共振成像（fMRI）通常在常规MRI检查结束时进行，在此期间，根据临床指征，已注射了造影剂；然而，钆喷酸葡胺（Gd-DTPA）注射对血氧水平依赖（BOLD）-fMRI结果的影响仍不清楚。本研究旨在探讨静脉注射Gd-DTPA对3T场强下通过BOLD-fMRI进行的初级运动皮层术前定位结果的影响。本研究纳入了8名正常受试者。在进行解剖扫描后，进行了对比剂注射前后的fMRI扫描。比较了显著激活体素的数量和平均信号变化百分比。对比剂注射前扫描中显著激活体素的平均数量为115.0±27.0，对比剂注射后扫描中为90.8±27.1（所有8名志愿者的平均值±标准差；p<0.05）。对比剂注射前扫描中平均信号变化百分比为4.07±0.39，对比剂注射后扫描中为3.86±1.91（p=0.16）。应在注射Gd造影剂之前通过BOLD-fMRI进行运动区的术前定位。
