Siluk Jarosław
Katedry i Kliniki Chirurgii Szczekowo-Twarzowej Pomorskiej Akademii Medycznej w Szczecinie, al. Powstańców Wlkp. 72, 70-111 Szczecin.
Ann Acad Med Stetin. 2002;48:135-43.
Orbital fractures are often accompanied by periosteal rupture and oculomotor muscle injury from the orbital fissure (blowout fracture). During reconstruction, substitute material (biomaterial) restoring the orbit is placed on a bony shelf and brought into direct contact with muscles and indirect contact with the eyeball, optic nerve and lacrimal gland. Histological examination of orbital tissues following reconstruction with titanium mesh, not possible in humans, can be performed in a rat model. In spite of different anatomy, the rats orbit was found satisfactory for the purpose of this study. The eyeball is supported by oculomotor muscles, lying partly on the malar bone. The aim was to follow the reaction of periorbital soft tissues to titanium mesh in a rat model of inferior orbital wall injury simulating orbital muscle lesions in man caused by blowout fracture. Insertion of titanium mesh directly in contact with muscles reproduced the situation in the human orbit. The following soft tissues and organs were studied: striated oculomotor muscle (inferior rectus), sclera, choroid, optic nerve and lacrimal gland. The results were compared with sham-operated animals (titanium mesh not implanted). Two questions were addressed: Is the process of healing of orbital muscle injury affected by the titanium mesh? Is there any evidence of adverse effect on periorbital soft tissues or eye of titanium wear particles produced by contraction of orbital muscles? Buffalo rats of the 38th generation and smooth titanium mesh (Ti-6AI-4V alloy) measuring 0.2 x 8 x 8 mm were used.
眼眶骨折常伴有眶骨膜破裂以及眶裂处的动眼肌损伤（爆裂性骨折）。在重建过程中，用于修复眼眶的替代材料（生物材料）被放置在骨架上，并与肌肉直接接触，与眼球、视神经和泪腺间接接触。用钛网重建后眼眶组织的组织学检查在人体中无法进行，但可在大鼠模型中进行。尽管解剖结构不同，但本研究发现大鼠眼眶足以满足研究目的。眼球由动眼肌支撑，部分位于颧骨上。本研究旨在通过模拟人类爆裂性骨折导致的眼眶肌肉损伤的大鼠眶下壁损伤模型，观察眶周软组织对钛网的反应。将钛网直接插入与肌肉接触的位置，重现了人类眼眶的情况。研究了以下软组织和器官：眼外直肌（下直肌）、巩膜、脉络膜、视神经和泪腺。将结果与假手术动物（未植入钛网）进行比较。研究了两个问题：钛网是否会影响眼眶肌肉损伤的愈合过程？是否有证据表明眼眶肌肉收缩产生的钛磨损颗粒会对眶周软组织或眼睛产生不良影响？使用了第38代布法罗大鼠和平滑钛网（Ti-6AI-4V合金），尺寸为0.2×8×8毫米。
