口腔鳞状细胞癌围手术期输血的预后意义
Prognostic significance of perioperative blood transfusion in oral cavity squamous cell carcinoma.
作者信息
Taniguchi Yoshitaka, Okura Masaya
机构信息
The First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-city, Osaka 565-0871, Japan.
出版信息
Head Neck. 2003 Nov;25(11):931-6. doi: 10.1002/hed.10313.
BACKGROUND
The influence of perioperative blood transfusion on survival in squamous cell carcinoma of the head and neck is still not convincingly determined. To investigate the effect of perioperative allogeneic transfusion on survival in stage II-IV squamous cell carcinoma of the oral cavity, we studied a consecutive series of 105 patients undergoing primary tumor resection and neck dissection.
METHODS
Retrospective analyses were performed using Cox proportional hazards models with 16 variables.
RESULTS
Perioperative red blood cell transfusion was required in 64 (61%) patients. Multivariate analysis demonstrated that the number of positive nodes and > or =3 units of red blood cell transfusion were an independent prognostic indicators. The calculated odds ratio for death after > or =3 units transfused was 5.79 (95% confidence interval, 1.56-21.53, p <.01).
CONCLUSIONS
More than 3 units of allogeneic red blood cells transfused might shorten the survival of patients with oral cavity cancer.
背景
围手术期输血对头颈部鳞状细胞癌患者生存率的影响仍未得到确切定论。为研究围手术期异体输血对Ⅱ - Ⅳ期口腔鳞状细胞癌患者生存率的影响，我们对连续的105例行原发性肿瘤切除及颈部清扫术的患者进行了研究。
方法
采用Cox比例风险模型对16个变量进行回顾性分析。
结果
64例（61%）患者围手术期需要输注红细胞。多因素分析表明，阳性淋巴结数量以及输注≥3单位红细胞是独立的预后指标。输注≥3单位红细胞后死亡的计算比值比为5.79（95%置信区间，1.56 - 21.53，p <.01）。
结论
输注超过3单位异体红细胞可能会缩短口腔癌患者的生存期。
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