Barra S, Barzan L, Maione A, Cadelano A, Pin M, Franceschi S, Comoretto R
Epidemiology Unit, Aviano Cancer Centre, Italy.
Laryngoscope. 1994 Jan;104(1 Pt 1):95-8. doi: 10.1288/00005537-199401000-00017.
The clinical records of 207 patients with squamous cell carcinoma of the head and neck, diagnosed and surgically treated at the Otolaryngology Division of Pordenone General Hospital and Aviano Cancer Centre, northeast of Italy, from January 1982 to December 1987, were retrospectively reviewed to gather information on blood transfusions and other characteristics potentially related to survival. The group of patients (mean age = 59 years) included 85 cases (41%) of laryngeal cancer, 80 cases (39%) of oropharyngeal and hypopharyngeal cancer, and 34 cases (16%) of cancer of the oral cavity. Fifty-five patients (27%) did not receive any blood transfusion while 152 patients were transfused with different amounts of blood. At the univariate analysis, nodal involvement, clinical stage, type of therapy, status of surgical margins, and metastatic spread beyond the nodal capsule appeared to be significantly linked to prognosis. After adjustment for other prognostic variables, transfused patients showed a twofold higher hazard ratio as compared to nontransfused patients, but such an unfavorable predictive value should be evaluated in the context of the other prognostic correlates of cancer of the head and neck.
回顾性分析了1982年1月至1987年12月期间在意大利东北部波代诺内综合医院耳鼻喉科和阿维亚诺癌症中心诊断并接受手术治疗的207例头颈部鳞状细胞癌患者的临床记录，以收集有关输血及其他可能与生存相关特征的信息。患者组（平均年龄=59岁）包括85例（41%）喉癌、80例（39%）口咽和下咽癌以及34例（16%）口腔癌。55例患者（27%）未接受任何输血，而152例患者接受了不同量的输血。单因素分析显示，淋巴结受累、临床分期、治疗类型、手术切缘状态以及超出淋巴结包膜的转移扩散似乎与预后显著相关。在对其他预后变量进行校正后，与未输血患者相比，输血患者的风险比高出两倍，但这种不利的预测价值应在头颈部癌症的其他预后相关因素的背景下进行评估。
