使用镍盐并结合微波促进实现芳基溴化物和氯化物的快速、简便氰化反应。
Rapid, easy cyanation of aryl bromides and chlorides using nickel salts in conjunction with microwave promotion.
作者信息
Arvela Riina K, Leadbeater Nicholas E
机构信息
Department of Chemistry, King's College London, Strand, London WC2R 2LS, United Kingdom.
出版信息
J Org Chem. 2003 Nov 14;68(23):9122-5. doi: 10.1021/jo0350561.
PMID:14604393
Abstract
We report here a fast, easy, and efficient method for the preparation of aryl nitriles from aryl bromides and chlorides. The methodology for aryl bromides involves the use of either Ni(CN)(2) or NaCN and NiBr(2). With aryl chlorides, a mix of NaCN and NiBr(2) is used and the reaction proceeds via the in situ formation of the corresponding aryl bromide. The reaction can be performed in air and is complete within 10 min.
摘要
我们在此报告一种由芳基溴化物和氯化物制备芳基腈的快速、简便且高效的方法。对于芳基溴化物的方法，涉及使用Ni(CN)₂或NaCN与NiBr₂。对于芳基氯化物，则使用NaCN和NiBr₂的混合物，反应通过原位形成相应的芳基溴化物进行。该反应可在空气中进行，且在10分钟内完成。
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