Gupta P C, Mehta F S, Pindborg J J, Bhonsle R B, Murti P R, Daftary D K, Aghi M B
Basic Dental Research Unit, Tata Institute of Fundamental Research, Bombay, India.
J Oral Pathol Med. 1992 Nov;21(10):433-9. doi: 10.1111/j.1600-0714.1992.tb00970.x.
Oral cancer is caused by chewing and smoking of tobacco. To assess the feasibility of primary prevention of oral cancer, two cohorts were studied in base-line surveys and then followed up annually for 10-yr in Ernakulam district of Kerala state. The intervention cohort consisted of 12212 tobacco users aged 15 yr and over, who were exposed to a concentrated program of education against tobacco use. The control cohort was a non-concurrent cohort of 6075 tobacco users studied using similar methods but with a minimal amount of advice against tobacco use. The stoppage of tobacco use increased and the incidence rate of leukoplakia decreased significantly and substantially in the intervention cohort compared to the control cohort. The decrease in the incidence of leukoplakia was indicative of the decrease in the risk of oral cancer since the two were intimately related. This study demonstrated feasibility of primary prevention of oral cancer.
口腔癌是由咀嚼烟草和吸烟引起的。为评估口腔癌一级预防的可行性，在喀拉拉邦埃纳库拉姆地区进行了两项队列研究，先是基线调查，然后每年随访10年。干预队列由12212名15岁及以上的烟草使用者组成，他们接受了针对烟草使用的集中教育项目。对照队列是一个非同期队列，有6075名烟草使用者，采用类似方法进行研究，但仅给予极少的控烟建议。与对照队列相比，干预队列中烟草使用的停止率增加，白斑发病率显著大幅下降。白斑发病率的下降表明口腔癌风险降低，因为二者密切相关。这项研究证明了口腔癌一级预防的可行性。
